Head of Department:
Prof. Dr. med. Dr. h. c. Heinrich Iro


With an Abbe refractometer (AR4 of Krüss) even small amounts of samples can be measured quickly. The device is suitable for solid or pasty samples as well as liquids.


Quanfication of the drug payload and other small molecules of nano-scaled systems. Waters Alliance System, Separation Module e2695 with UV/Vis Detector 2489 coupled with an MS Acquity SQD.

available columns (specs):

verfügbare HPLC Säulen
NameMaterialPore SizeDimensions
xBrigdeShield PR 183,53,0 x 100mm
xBrigdeC83,53,0 x 100mm
xBrigdePhenyl3,53,0 x 100mm
xBrigdePhenyl3,53,0 x 150mm
PAHC1854,6 x 250mm


Highly selective quantitation of drugs and other small molecules compounds of nanoparticles with the Thermo Scientific Ultimate 3000 HPLC system with SQ EC mass detector.

Zeta-Potential Measurement

Malvern Zetasizer Nano ZS:
It is used to measure the size, electrophoretic mobility of proteins, the zeta potential of colloids and nanoparticles, and (optionally) to measure protein mobility and microrheological measurement of protein and polymer solutions.

Particle-size Measurement

Nicomp Zeta Potential/ Particle Sizer 380 ZLS: hydrodynamic particle size measurement using dynamic light scattering in a range of 1-1000 nm.

Nanophox from Sympatec: additionally particle size and stability analysis with "Photon Cross-correlation Spectroscopy" (PCCS) from 1 nm up to 10 µm in opaque suspensions and emulsions.

UV/VIS - Photometry

Quantification of chromophores either directly or after derivatization. Kinetic experiments or direct measurements possible. Specific application: Acquisition of the total iron content of iron-oxide-based particle dispersions. Biochrom Libra S22 – Spectrometer.


Freeze-drying is based on the physical process of sublimation: During freeze drying the ice crystals sublimate without intermediate occurrence of a liquid phase directly into the gaseous state. By Christ Alpha 1-2 LD Plus therefore we have a device available that is suitable for the gentle drying of quality products.

Tangential Flow Filtration System

The KrosFlo ® Research IIi by Spectrum Labs is suitable for microfiltration and ultrafiltration of both small volumes of 1 ml and larger amounts up to 10 l. The system covers crossflow rates from 0.01 to 2300 ml / min with a pump head and up to 3800 ml / min with an optional second pump head. Therefore samples can be carefully concentrated

Closed Vessel Microwave Digestion

Digestion and synthesis using microwave as automatic, pre-programmed sequences. It can proceed pressure-free reactions and reaction processes which are carried out in pressure vessels. At our disposal is a Discover Explorer SPD including automatic sample changer by CEM.

Microwave Plasma-Atomic Emission Spectrometer

Our Microwave Plasma-Atomic Emission Spectrometer (4200 MP-AES Agilent) enables us to measure numerous elements, partly down to some nanograms per milliliter in tissue samples. Our system is equipped with an automatic sample changer, with which up to 180 samples can be measured automatically in succession.


Basic characterization of organic compounds detecting specific chemical bonds. Surface characterization and/or direct verification of organic compounds is possible. Bruker ALPHA FT-IR spectrometer, Platinum-ATR-sample module and QuickSnap™ transmission module.


The DV3T of Brookefield can determine the viscosity and yield points even of small sample volumes (0.5 mL).

Mini pilot installation for GMP / FDA compliant syntheses

Consisting of a double walled 2 liter glass reactor enabeling reaction temperatures of - 60°C to + 200°C. Dry running shaft sealing; highly corrosion-resistant material made of glass, PTFE and PEEK components. Manual lowering device. The reaction chamber is CIP capable (Cleaning in Place).

The modular design enables the exchange of components to accommodate different synthesis requirements.

All assemblies are mounted on a stainless mobile rack.

The following applications are possible: distillation, evaporation to any desired consistency, multi-component-reactions, gas inlet, extraction, crystallization and precipitations.

The specifically for particle synthesis designed cover plate includes following features: a dosing unit, a hand hole for the addition of starting material, an inert gas supply, a shaft feedthrough for stirring the mixture, a reflux condenser and a pressure gauge attached to the pressure monitoring. This allows a small step parameterization process for synthesis transfer from the laboratory scale to up-scaled production volumes under quality controlled conditions.

magnetic susceptibility meter MS2G/ MS3

This sensor is designed for magnetic susceptibility measurements of 1ml liquid or powder samples. Calibrated volume is 1ml but scaling correction values allow volumes down to 0.2ml to be measured. The sensor operates at a low frequency and has excellent temperature stability. The MS2G is used for susceptibility measurements where only very small samples of homogeneous fine-grained material are available: for example, airborne particulates collected in filter, or particles in colloidal suspension.


Efficiency system for analyzing the charge characteristics of nanoparticles and polyelectrolytes.
Method: The heart of the Stabino® is a cylindrical PTFE measuring cup with an oscillating pestle. Part of the particles is immobilized on the surface of the cell wall. As a result of the piston movement, the mobile charge cloud of each double layer is pushed up and down the immobilized particles. The oscillating ion cloud thus generates an alternating voltage = flow potential at both electrodes. This voltage is proportional to the zeta potential of the particles.


10 years SEON
Nanopartikel mit Ultraschall sichtbar machen
Manfred-Roth-Foundation supports SEON research project

Donations account

Forschungsstiftung Medizin at the Universitätsklinikum Erlangen

Sparkasse Erlangen
IBAN: DE 69 76350000 0000062000
Intended use:
Nanomedizin Prof. Alexiou

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Comprehensive Cancer Center
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