Analytics

Otorhinolaryngology

Head of Department:
Prof. Dr. med. Dr. h. c. Heinrich Iro

Refractometry

With an Abbe refractometer (AR4 of Krüss) even small amounts of samples can be measured quickly. The device is suitable for solid or pasty samples as well as liquids.

HPLC (UV- MS)

Quanfication of the drug payload and other small molecules of nano-scaled systems. Waters Alliance System, Separation Module e2695 with UV/Vis Detector 2489 coupled with an MS Acquity SQD.

available columns (specs):

verfügbare HPLC Säulen
NameMaterialPore SizeDimensions
xBrigdeShield PR 183,53,0 x 100mm
xBrigdeC83,53,0 x 100mm
xBrigdePhenyl3,53,0 x 100mm
xBrigdePhenyl3,53,0 x 150mm
PAHC1854,6 x 250mm

LC-MS/MS

Highly selective quantitation of drugs and other small molecule compounds of nanoparticles. Verification of HPLC (UV-MS) derived data. Agilent Series 1100 HPLC coupled with a tiple quadrupol mass detector (Applied Biosystems, Sciex API 2000).

Zeta-Potential Measurement

Measurement of the electrical potential at the surrounding shear surface in water based suspensions. Estimation of the stability of suspensions (in addition to particle sizes). Nicomp Zeta Potential/ Particle Sizer 380 ZLS.

Particle-size Measurement

Nicomp Zeta Potential/ Particle Sizer 380 ZLS: hydrodynamic particle size measurement using dynamic light scattering in a range of 1-1000 nm.

Nanophox from Sympatec: additionally particle size and stability analysis with "Photon Cross-correlation Spectroscopy" (PCCS) from 1 nm up to 10 µm in opaque suspensions and emulsions.

UV/VIS - Photometry

Quantification of chromophores either directly or after derivatization. Kinetic experiments or direct measurements possible. Specific application: Acquisition of the total iron content of iron-oxide-based particle dispersions. Biochrom Libra S22 – Spectrometer.

Freeze-dryer

Freeze-drying is based on the physical process of sublimation: During freeze drying the ice crystals sublimate without intermediate occurrence of a liquid phase directly into the gaseous state. By Christ Alpha 1-2 LD Plus therefore we have a device available that is suitable for the gentle drying of quality products.

Tangential Flow Filtration System

The KrosFlo ® Research IIi by Spectrum Labs is suitable for microfiltration and ultrafiltration of both small volumes of 1 ml and larger amounts up to 10 l. The system covers crossflow rates from 0.01 to 2300 ml / min with a pump head and up to 3800 ml / min with an optional second pump head. Therefore samples can be carefully concentrated

Closed Vessel Microwave Digestion

Digestion and synthesis using microwave as automatic, pre-programmed sequences. It can proceed pressure-free reactions and reaction processes which are carried out in pressure vessels. At our disposal is a Discover Explorer SPD including automatic sample changer by CEM.

Microwave Plasma-Atomic Emission Spectrometer

Our Microwave Plasma-Atomic Emission Spectrometer (4200 MP-AES Agilent) enables us to measure numerous elements, partly down to some nanograms per milliliter in tissue samples. Our system is equipped with an automatic sample changer, with which up to 180 samples can be measured automatically in succession.

FTIR

Basic characterization of organic compounds detecting specific chemical bonds. Surface characterization and/or direct verification of organic compounds is possible. Bruker ALPHA FT-IR spectrometer, Platinum-ATR-sample module and QuickSnap™ transmission module.

Rheometry

The DV3T of Brookefield can determine the viscosity and yield points even of small sample volumes (0.5 mL).

Mini pilot installation for GMP / FDA compliant syntheses

Consisting of a double walled 2 liter glass reactor enabeling reaction temperatures of - 60°C to + 200°C. Dry running shaft sealing; highly corrosion-resistant material made of glass, PTFE and PEEK components. Manual lowering device. The reaction chamber is CIP capable (Cleaning in Place).

The modular design enables the exchange of components to accommodate different synthesis requirements.

All assemblies are mounted on a stainless mobile rack.

The following applications are possible: distillation, evaporation to any desired consistency, multi-component-reactions, gas inlet, extraction, crystallization and precipitations.

The specifically for particle synthesis designed cover plate includes following features: a dosing unit, a hand hole for the addition of starting material, an inert gas supply, a shaft feedthrough for stirring the mixture, a reflux condenser and a pressure gauge attached to the pressure monitoring. This allows a small step parameterization process for synthesis transfer from the laboratory scale to up-scaled production volumes under quality controlled conditions.

 

 

 

 

 
News

Potenziale der Nanomedizin
Europaabgeordnete Monika Hohlmeier
besucht SEON

Erlangen soll Leuchtturm werden
Oberbürgermeister Florian Janik sagt
Unterstützung zu

First poster award: Dr. Ralf Friedrich
16th Ferrofluid-Workshop 2017, Dresden, Germany

Second poster award: Dr. Marina Pöttler
10th International Conference CLINAM 2017, Basel, Switzerland

Highlights

Forschung mit anziehender Wirkung
Manfred-Roth-Stiftung unterstützt SEON-Turmorforschung der HNO-Klinik mit 50.000 Euro

Physik-Nobelpreisträger Prof. Dr. Gerd Binnig zu Gast in der HNO-Klinik

Donations account

Forschungsstiftung Medizin at the University Hospital of Erlangen

Sparkasse Erlangen
IBAN: DE 69 76350000 0000062000
Intended use:
Nanomedizin Prof. Alexiou

Certifications
Text TÜV Süd auf weißem Grund umgeben von achteckigen blauen Ring in dem in weißer Schrift ISO 9001 steht
 
 
 
 
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Summary