The voice is the most important instrument of oral communication, therefore losing one’s ability to communicate over speech due to tissue defects in the area of the vocal folds, lead to serious aggravation in the quality of life. The vocal fold, with its unique structure, is a prerequisite for voice production. Human vocal folds undulate with wavelike movements in response to the airflow from the lung. Thereby, they collide with each other more than hundreds of times per second in order to produce the voice.
The vocal fold is a relatively new target for tissue engineering attempts. Nevertheless, a lot of improvement has been made for rheological, histological and functional outcomes but, complete rescue of native vocal fold tissue function and structure has not been achieved so fare. Therefore, techniques to manipulate and remotely control cellular behavior can deliver a powerful tool for tissue engineering.
We use superparamagnetic iron oxide nanoparticles (SPION) for Magnetic Tissue Engineering (MTE) to generate 3D-multilayered vocal fold cell-constructs. The underlying concept includes cellular uptake of SPIONs and the use of external magnetic fields to associate cells in a 3D cell-construct. This will constitute a solid basis for a successful transfer of this technique into humans, in order to provide an individual and personalized vocal fold transplant.
Publications can be reviewd on PubMed .
"Funktionelles Tissue Engineering der menschlichen Stimmlippe mit superparamagnetischen Eisenoxidnanopartikeln – Magnetic Tissue Engineering (MTE)", 2019-2021
Prof. Bengt Fadeel
Karolinska Institute, Sweden
Univ.-Prof. Harald Mangge
Medical University Graz, Austria
Dr. Didier Letourneur
French Institute of Health and Medical Research Paris, French
Prof. Dr. Matthias Graw, Dr. Christian Braun
Institut of Forensic Medicine, Ludwig-Maximilians-Universität München, Germany
Prof. Dr. Oliver Friedrich
Friedrich-Alexander-Universität Erlangen-Nürnberg, Medical Biotechnology
Prof. Dr. Christian Pilarsky
Clinic for Surgery, Translational Research Center, Universitätsklinikum Erlangen, Germany
Forschungsstiftung Medizin at the Universitätsklinikum Erlangen
IBAN: DE 69 76350000 0000062000
Nanomedizin Prof. Alexiou