The voice is the most important instrument of oral communication, therefore losing one’s ability to communicate over speech due to tissue defects in the area of the vocal folds, lead to serious aggravation in the quality of life. The vocal fold, with its unique structure, is a prerequisite for voice production. Human vocal folds undulate with wavelike movements in response to the airflow from the lung. Thereby, they collide with each other more than hundreds of times per second in order to produce the voice.
The vocal fold is a relatively new target for tissue engineering attempts. Nevertheless, a lot of improvement has been made for rheological, histological and functional outcomes but, complete rescue of native vocal fold tissue function and structure has not been achieved so fare. Therefore, techniques to manipulate and remotely control cellular behavior can deliver a powerful tool for tissue engineering.
We use superparamagnetic iron oxide nanoparticles (SPION) for Magnetic Tissue Engineering (MTE) to generate 3D-multilayered vocal fold cell-constructs. The underlying concept includes cellular uptake of SPIONs and the use of external magnetic fields to associate cells in a 3D cell-construct. This will constitute a solid basis for a successful transfer of this technique into humans, in order to provide an individual and personalized vocal fold transplant.
Publications can be reviewd on PubMed .
Prof. Bengt Fadeel
Karolinska Institute, Sweden
Univ.-Prof. Harald Mangge
Medizinische Universität Graz, Austria
PhD Didier Letourneur
French Institute of Health and Medical Research Paris, French
Dr. med. Christian Braun
Ludwig-Maximilians-Universität München, Germany
DFG fördert 15 neue
SEON an SFB/Transregio
Magnetpartikelforschung will Patienten
ihre Stimme zurückgeben
Forschungsstiftung Medizin spenden
50.000 Euro für die Entwicklung
Potenziale der Nanomedizin
Europaabgeordnete Monika Hohlmeier
Forschungsstiftung Medizin at the University Hospital of Erlangen
IBAN: DE 69 76350000 0000062000
Nanomedizin Prof. Alexiou