Synthesis and Characterization

Otorhinolaryngology

Head of Department:
Prof. Dr. med. Dr. h. c. Heinrich Iro

Projects

The aim of our department is the development of new nanoparticular systems for drug delivery, hyperthermia, and imaging. The discovery of biocompatible and highly efficient carrier systems with the aim of their translation into clinical practice is the center of our attention. All of our syntheses are based on precipitation reactions in alkaline media with which we produce magnetic nanoparticles. These particles can afterwards be coated with various substances and loaded with drugs. The latter can be done by either adsorption or chemical bonding. To categorize the respective effects of the particles in vivo – be they wanted or unwanted – they have to be thoroughly analyzed for their physicochemical structure and shape. The size of the aggregates is a crucial parameter here, one we can analyze by Dynamic Light Scattering. The morphology and size of the single particles can be examined with Transmission Electron Microscopy (TEM). The electrostatic potential of particles in a shear plane –the Zeta potential- is an important parameter for the colloidal stability, and is also investigated. The content of drugs and other moieties is quantified by HPLC/UV-MS. The particle surface is analyzed by FTIR, a method with which the chemical bonding situation on the surface can be investigated. This contributes significantly to the success of the specific tailoring of particle surfaces. In cooperation with our partner, the pharmacy of the university hospital, we also operate a fully functional GMP unit for the quality-controlled synthesis of nanoparticles with a clinical approach.


Leadership and Contact


Deputy


Staff


Publications

Publications can be reviewed on PubMed.



 
News

Matthias-Lorenz-Forschungspreis
Nanomedizinische Forschung ausgezeichnet

Neue Kontrastmittel aus Nanopartikeln
40.000 € Spende von der
Manfred-Roth-Stiftung

Zellen live beobachten
46.000 € Spende ermöglicht
Anschaffung eines 3-D-Live-Zellmikroskops

Donations account

Forschungsstiftung Medizin at the Universitätsklinikum Erlangen

Sparkasse Erlangen
IBAN: DE 69 76350000 0000062000
Intended use:
Nanomedizin Prof. Alexiou

Certifications
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Comprehensive Cancer Center
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