The aim of our department is the development of new nanoparticular systems for drug delivery, hyperthermia, and imaging. The discovery of biocompatible and highly efficient carrier systems with the aim of their translation into clinical practice is the center of our attention. All of our syntheses are based on precipitation reactions in alkaline media with which we produce magnetic nanoparticles. These particles can afterwards be coated with various substances and loaded with drugs. The latter can be done by either adsorption or chemical bonding. To categorize the respective effects of the particles in vivo – be they wanted or unwanted – they have to be thoroughly analyzed for their physicochemical structure and shape. The size of the aggregates is a crucial parameter here, one we can analyze by Dynamic Light Scattering. The morphology and size of the single particles can be examined with Transmission Electron Microscopy (TEM). The electrostatic potential of particles in a shear plane –the Zeta potential- is an important parameter for the colloidal stability, and is also investigated. The content of drugs and other moieties is quantified by HPLC/UV-MS. The particle surface is analyzed by FTIR, a method with which the chemical bonding situation on the surface can be investigated. This contributes significantly to the success of the specific tailoring of particle surfaces. In cooperation with our partner, the pharmacy of the university hospital, we also operate a fully functional GMP unit for the quality-controlled synthesis of nanoparticles with a clinical approach.
Publications can be reviewed on PubMed.
Prof. Dr. Peter Wasserscheid
University of Erlangen-Nuremberg, Institute for Chemical Reaction Engineering
Prof. Dr. -Ing. habil. Aldo R. Boccaccini
University of Erlangen-Nuremberg, Institute for Biomaterials
Prof. Dr. med. Hans Drexler
Prof. Dr. med. Simone Schmitz-Spanke
University of Erlangen-Nuremberg, Department of Occupationsl Medicine
Prof. Dr. Lutz Trahms
Physikalisch-Technische Bundesanstalt Berlin, Department 8.2 (Biosignals)
Prof. Dr. rer. nat. habil. Stefan Odenbach
Chair of Magnetofluiddynamics, Measurement and Automation Technology
Dr. phil.nat. Frank Dörje University Hospital of Erlangen, Pharmacy
für intelligente Datenvernetzung
Staatsministerin Ilse Aigner
DFG fördert 15 neue
SEON an SFB/Transregio "BioFab"
Forschungsstiftung Medizin at the Universitätsklinikum Erlangen
IBAN: DE 69 76350000 0000062000
Nanomedizin Prof. Alexiou